Synthesis, Spectral characterization and antimicrobial activity of 2-(substituted)-2,2-[1,3- dihydro-(3,4-1,2,5-oxadiazolediyl) diaza][5 ׳ , 5 ׳ -dimethyl-1 ׳ , 3 ׳ -propanediyl) dioxy] phosphoranes
Y. Hari Babu, A. Uma Ravi Sankar, B. Siva Kumar and C. Suresh Reddy
Org. Commun. (2010), 3:1 ; 15-21
Department of Chemistry, Sri Venkateswara University, Tirupati – 517502, India.
Japan Association for the Advancement of Medical Equipment (JAAME), Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Abstract: The cyclic oxadiazolediyl dioxachlorophosphine precursor on subsequent reaction with various alcohols underwent halide displacement to give 2-substituted diaza phospholes. These phospholes on oxidative addition with di hydroxy alcohols form corresponding phosphoranes The antimicrobial activities of these compounds were evaluated and they exhibited significant antimicrobial activity.
Keywords: Spirophosphoranes; dioxaphosphoranes; antimicrobial activity; P(III) to P(V);
N-chlorodiisopropylamine. |